Article 2025 · 3 atıf

Deep eutectic solvents assisted green extraction and bioevaluation of phenolic compounds from <i>Piper nigrum</i> and <i>Murraya koenigii</i>

Awari, Ankita, Kaushik, Deepika, Oz, Fatih, Kumar, Mukul

Özet

Deep eutectic solvents (DESs) for extracting bioactives from Piper nigrum and Murraya koenigii, focusing on the effects of temperature and molar composition. Choline chloride-malonic acid DESs exhibited reduced viscosity with increasing temperature (1.78 to 1.276 mPa & sdot;s from 50 degrees C to 90 degrees C at 1:1.5 ratio), enhancing mass transfer. Thermal analysis confirmed low melting points and high stability, supporting their use in thermally assisted extraction. Optimal extraction occurred at 60 degrees C for P. nigrum (1:1.5) and 80 degrees C for M. koenigii (1:0.5). Acetone purification improved compound purity without major yield loss. Piperine and mahanimbine levels reached 10.34 % and 12 % w/w, respectively. Although DES extracts showed slightly lower lipid digestion inhibition than raw powders, their biocompatibility, low cytotoxicity, and potential to enhance bioavailability highlight their promise in sustainable functional food applications.

Anahtar Kelimeler

Anti-solvent purification Bioactive compound extraction Deep eutectic solvents (DESs) Extraction efficiency In vitro inhibition assay NATURAL-PRODUCTS CHOLINE CHLORIDE IONIC LIQUIDS MIXTURES ACIDS FLAVONOIDS SEPARATION MEDIA

WoS Kategorileri

Chemistry, Applied Food Science & Technology Nutrition & Dietetics

Künye

Dergi: FOOD CHEMISTRY
Yıl: 2025
Cilt: 493
ISSN: 0308-8146
eISSN: 1873-7072
DOI: 10.1016/j.foodchem.2025.145931
WoS UID: WOS:001554423700003

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