Review 2025 · 5 citations

Advances of functional nucleic acids based on specific recognition:A review

Liu, Beibei, Chen, Ge, Abd El-Aty, A. M., Zhai, Rongqi, Liu, Guangyang, Xu, Xiaomin, Zhang, Yanguo, Li, Lingyun, Zhang, Jie, Xu, Donghui

Abstract

Nucleic acids, which are fundamental to living organisms, play a crucial role in carrying and transmitting genetic information. Advances in molecular biology have led to the exploration of functional nucleic acids (FNAs), including aptamers, DNAzymes, and G-quadruplexes, known for specific recognition or catalysis. FNAs with high specificity, sequence programmability, modification ease and biocompatibility, have extensive applications in biosensing, environmental monitoring, drug delivery and cancer diagnosis. This review focuses on the structure and specific recognition principles of FNAs, followed by an exploration for biosensing and biomedical applications, offering insights into current challenges and future trends in FNAs as recognition elements.

Keywords

Functional nucleic acids Specific recognition Application IN-VITRO SELECTION G-QUADRUPLEX DNA APTAMER DNAZYME PROBE RNA DELIVERY ION APTASENSOR

WoS Categories

Biochemistry & Molecular Biology Chemistry, Applied Polymer Science

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Year: 2025
Volume: 304
ISSN: 0141-8130
eISSN: 1879-0003
DOI: 10.1016/j.ijbiomac.2025.140828
WoS UID: WOS:001426616400001

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