Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates
Özet
In this article, we are reporting a series of di-and tri-organotin(IV) carboxylate complexes (1–4) derived from the reaction of sodium-3-bromophenylacetate (NaL) with (CH3)2SnCl2, (C4H9)2SnCl2, (CH3)3SnCl and (C4H9)3SnCl in dried toluene while refluxing for 8 h. The desired organotin(IV) derivative were analyzed by elemental analyzer, FTIR, NMR and single crystal XRD. The antimicrobial data against the tested bacterial strains follow the order: 2 > 4 > 3 > 1 > HL. The anticancer potential of the synthesized compounds was evaluated against the lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) and it was observed that 4 was the highly cytotoxic against A549 while HL and 1 showed no cytotoxicity against MRC-5, neither at lower or higher concentrations.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Gul, R., Muhammad, N., Sirajuddin, M., Noor, A., Tumanov, N., Wouters, J., Chafik, A., Solak, K., Mavi, A., Shujah, S., Ali, S., Khan, G. S., & Qayyum, S. (2024). Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates. Journal of Molecular Structure, 1300. https://doi.org/10.1016/j.molstruc.2023.137306
BibTeX
@article{gul2024-80788,
author = {Gul, Roshni and Muhammad, Niaz and Sirajuddin, Muhammad and Noor, Awal and Tumanov, Nikolay and Wouters, Johan and Chafik, Abdelbasset and Solak, Kübra and Mavi, Ahmet and Shujah, Shaukat and Ali, Saqib and Khan, Gul Shahzada and Qayyum, Sadaf},
title = {Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates},
journal = {Journal of Molecular Structure},
year = {2024},
volume = {1300},
issn = {0022-2860},
doi = {10.1016/j.molstruc.2023.137306},
url = {https://akademik.atauni.edu.tr/yayinlar/80788-design-physicochemical-confirmation-single-crystal-structures-as-well-as}
}