Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation

Avcibasi, Ugur; Turkyarar, Taner; Karadag, Aysegul; Bakan, Buket; Yavasoglu, Nefise Ulku Karabay; Kusat, Kevser; AKGÖL, SİNAN; GÜLCEMAL, DERYA; Tekin, Volkan; BİBER MÜFTÜLER, FAZİLET ZÜMRÜT; Topal, Gokcen; Parlak, Yasemin; Gumuser, Fikriye Gul

doi:10.1007/s10967-021-07817-6

Makale Tam Makale Uluslararası 2021

Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation

Ugur Avcibasi, Taner Turkyarar, Aysegul Karadag, Buket Bakan, Nefise Ulku Karabay Yavasoglu, Kevser Kusat, SİNAN AKGÖL, DERYA GÜLCEMAL, Volkan Tekin, FAZİLET ZÜMRÜT BİBER MÜFTÜLER, Gokcen Topal, Yasemin Parlak, Fikriye Gul Gumuser

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY Cilt 329 · ss. 511–525 · 01.08.2021

DOI ile aç

Özet

The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.

Anahtar kelimeler

SIZE FUTURE THERAPY toxicity cytotoxicity DELIVERY adsorption PROLINE MAGNETIC NANOPARTICLES Nanopolymer Graft Polymer Tc-99m Radiolabeling BIODISTRIBUTION

Atıf için künye

Avcibasi, U., Turkyarar, T., Karadag, A., Bakan, B., Yavasoglu, N. U. K., Kusat, K., AKGÖL, S., GÜLCEMAL, D., Tekin, V., BİBER MÜFTÜLER, F. Z., Topal, G., Parlak, Y., & Gumuser, F. G. (2021). Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 329, 511–525. https://doi.org/10.1007/s10967-021-07817-6

BibTeX

@article{avcibasi2021-79619,
  author = {Avcibasi, Ugur and Turkyarar, Taner and Karadag, Aysegul and Bakan, Buket and Yavasoglu, Nefise Ulku Karabay and Kusat, Kevser and AKGÖL, SİNAN and GÜLCEMAL, DERYA and Tekin, Volkan and BİBER MÜFTÜLER, FAZİLET ZÜMRÜT and Topal, Gokcen and Parlak, Yasemin and Gumuser, Fikriye Gul},
  title = {Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation},
  journal = {JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY},
  year = {2021},
  volume = {329},
  pages = {511--525},
  issn = {0236-5731},
  doi = {10.1007/s10967-021-07817-6},
  url = {https://akademik.atauni.edu.tr/yayinlar/79619-preparation-of-a-tc-99m-labeled-graft-polymer-and-its-in-vitro-and-in-vivo}
}