Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes
Özet
In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, H-1, P-31 NMR techniques. Later, the effects of the synthesized compounds to DNA were screened using DNA interaction analysis and cleavage methods by utilizing pUC18 plasmid. The results showed that the compounds 14, 40 and 45 caused Form III (linearized DNA) plasmid DNA, indicating the interaction of these compounds with the plasmid DNA.
Anahtar kelimeler
Atıf için künye
Yıldırım, T., Şenkuytu, E., Ergene, E., Bilgin, K., Uludağ, Y., & Çiftçi, G. Y. (2018). Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes. ChemistrySelect, 3(34), 9933–9939. https://doi.org/10.1002/slct.201801766
BibTeX
@article{yildirim2018-79234,
author = {Yıldırım, Tuba and Şenkuytu, Elif and Ergene, Emel and Bilgin, Kemal and Uludağ, Yıldız and Çiftçi, Gönül Yenilmez},
title = {Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes},
journal = {ChemistrySelect},
year = {2018},
volume = {3},
number = {34},
pages = {9933--9939},
issn = {2365-6549},
doi = {10.1002/slct.201801766},
url = {https://akademik.atauni.edu.tr/yayinlar/79234-biological-activity-of-new-cyclophosphazene-derivatives-including-fluorenylidene}
}