A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy
Özet
In this study, we synthesized and characterized a silicon phthalocyanine substituted with 3-hydroxypyridin-2-thione (SiPc-HDACi), designed to be a chemophotodynamic therapy agent acting as a histone deacetylase inhibitor, and we determined its photophysical, photochemical, and photobiological properties. Next, we evaluated its anticancer efficacy on MCF-7, double positive and MDA-MB-231, triple negative breast cancer cell lines, as well as on a healthy human endothelial cell line (HUVEC). Our results indicate that SiPc-HDACi can target nucleoli of cells, effectively inducing apoptosis while promoting cell cycle arrest thanks to its high singlet oxygen yield and its histone deacetylase downregulating properties, suggesting a powerful anticancer effect on breast cancer in vitro. Our further studies will be conducted with primary breast cancer cell culture to give a better insight into the anticancer mechanism of the compound.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Aru, B., Günay, A., Şenkuytu, E., Yanlkkaya Demirel, G., Gürek, A. G., & Atilla, D. (2020). A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy. ACS OMEGA, 5(40), 25854–25867. https://doi.org/10.1021/acsomega.0c03180
BibTeX
@article{aru2020-79213,
author = {Aru, Başak and Günay, Aysel and Şenkuytu, Elif and Yanlkkaya Demirel, Gülderen and Gürek, Ayşe Gül and Atilla, Devrim},
title = {A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy},
journal = {ACS OMEGA},
year = {2020},
volume = {5},
number = {40},
pages = {25854--25867},
issn = {2470-1343},
doi = {10.1021/acsomega.0c03180},
url = {https://akademik.atauni.edu.tr/yayinlar/79213-a-translational-study-of-a-silicon-phthalocyanine-substituted-with-a-histone}
}