Design, Synthesis and Determination of Bisbenzazol Derivatives for Antiproliferative and Antimicrobial Activity
Özet
Developing of novel potent anticancer lead compounds presents one of the main objectives
of the study. An addition aim for the present study is that due to increasing drug resistance to
antimicrobial therapy, design and developing a novel drug candidate with alternate
mechanism of action as well as anticancer drugs with.
In the present study, 9 analogous of bisbenzazole synthesized by Philips and PPA methods as
three groups based on benzimidazole core structure. The structure of the compounds, was
elucidated by FT-IR, 1H-NMR and 13C-NMR. Their antiproliferative activity was investigated by
MTT (3-[4,5-dimethylthiazyl-2-yl]-2,5-diphenyltetrazolium bromide) method and
antimicrobial activity by modified microdilution method. Whereas bisbenzoxazole compounds
act as more potent antiprolifrative activity, bisbenzimidazole compounds have better
antimicrobial activity.
Atıf için künye
Polat, M. F., Ersan, R. H., Burmaoğlu, S., & Algül, Ö. (2020). Design, Synthesis and Determination of Bisbenzazol Derivatives for Antiproliferative and Antimicrobial Activity. 8. International Drug Chemistry Conference, Antalya (ss. 102–106).
BibTeX
@inproceedings{polat2020-79120,
author = {Polat, Muhammed Fatih and Ersan, Ronak Haj and Burmaoğlu, Serdar and Algül, Öztekin},
title = {Design, Synthesis and Determination of Bisbenzazol Derivatives for Antiproliferative and Antimicrobial Activity},
booktitle = {8. International Drug Chemistry Conference},
address = {Antalya},
year = {2020},
pages = {102--106},
url = {https://akademik.atauni.edu.tr/yayinlar/79120-design-synthesis-and-determination-of-bisbenzazol-derivatives-for}
}