Synthesis of Tetrasubstituted Pyrroles and Pyrrole-Based Chalcones and Investigation of Their Cytotoxic Effects on MCF-7 Cell Line
Özet
Some tetrasubstituted pyrrole derivatives from corresponding amines, acetylacetone and
nitrostyrenes were synthesized by using (diacetoxyiodo)benzene (DIB) at reflux temperature
in ethanol. Their chalcone derivatives were also synthesized via the base-catalyzed ClaisenSchmidt condensation reaction. All compounds were evaluated for their in vitro
antiproliferative activity against MCF-7 cancer cell line using MTT assay. Relationships
between structure and biological activity were determined by comparing their activity results.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Akbaşlar, D., Burmaoğlu, S., & Algül, Ö. (2020). Synthesis of Tetrasubstituted Pyrroles and Pyrrole-Based Chalcones and Investigation of Their Cytotoxic Effects on MCF-7 Cell Line. 8. International Drug Chemistry Conference, Antalya (ss. 154–158).
BibTeX
@inproceedings{akbaslar2020-79115,
author = {Akbaşlar, Dilek and Burmaoğlu, Serdar and Algül, Öztekin},
title = {Synthesis of Tetrasubstituted Pyrroles and Pyrrole-Based Chalcones and Investigation of Their Cytotoxic Effects on MCF-7 Cell Line},
booktitle = {8. International Drug Chemistry Conference},
address = {Antalya},
year = {2020},
pages = {154--158},
url = {https://akademik.atauni.edu.tr/yayinlar/79115-synthesis-of-tetrasubstituted-pyrroles-and-pyrrole-based-chalcones-and}
}