Sensing by Smell: Nanoparticle-Enzyme Sensors for Rapid and Sensitive Detection of Bacteria with Olfactory Output

DUNCAN, Bradley; Le, Ngoc D. B.; ALEXANDER, Colleen; GUPTA, Akash; Tonga, Gulen Yesilbag; YAZDANİ, Mahdieh; Landis, Ryan F.; WANG, Li-Sheng; YAN, BO; Burmaoğlu, Serdar; Lİ, Xiaoning; Rotello, Vincent M.

doi:10.1021/acsnano.7b00822

Makale Tam Makale Uluslararası 2017

Sensing by Smell: Nanoparticle-Enzyme Sensors for Rapid and Sensitive Detection of Bacteria with Olfactory Output

Bradley DUNCAN, Ngoc D. B. Le, Colleen ALEXANDER, Akash GUPTA, Gulen Yesilbag Tonga, Mahdieh YAZDANİ, Ryan F. Landis, Li-Sheng WANG, BO YAN, Serdar Burmaoğlu, Xiaoning Lİ, Vincent M. Rotello

ACS NANO Cilt 11 · Sayı 6 · ss. 5339–5343 · 01.06.2017

DOI ile aç

Özet

We present here a highly efficient sensor for bacteria that provides an olfactory output, allowing detection without the use of instrumentation and with a modality that does not require visual identification. The sensor platform uses nanoparticles to reversibly complex and inhibits lipase. These complexes are disrupted in the presence of bacteria, restoring enzyme activity and generating scent from odorless pro-fragrance substrate molecules. This system provides rapid (15 min) sensing and very high sensitivity (10(2) cfu/mL) detection of bacteria using the human sense of smell as an output.

Anahtar kelimeler

BACTERIA CELLS RELEASE ENZYMES ESCHERICHIA-COLI nanoparticles Self-assembly BIOSENSOR human olfaction

Atıf için künye

DUNCAN, B., Le, N. D. B., ALEXANDER, C., GUPTA, A., Tonga, G. Y., YAZDANİ, M., Landis, R. F., WANG, L., YAN, B., Burmaoğlu, S., Lİ, X., & Rotello, V. M. (2017). Sensing by Smell: Nanoparticle-Enzyme Sensors for Rapid and Sensitive Detection of Bacteria with Olfactory Output. ACS NANO, 11(6), 5339–5343. https://doi.org/10.1021/acsnano.7b00822

BibTeX

@article{duncan2017-79092,
  author = {DUNCAN, Bradley and Le, Ngoc D. B. and ALEXANDER, Colleen and GUPTA, Akash and Tonga, Gulen Yesilbag and YAZDANİ, Mahdieh and Landis, Ryan F. and WANG, Li-Sheng and YAN, BO and Burmaoğlu, Serdar and Lİ, Xiaoning and Rotello, Vincent M.},
  title = {Sensing by Smell: Nanoparticle-Enzyme Sensors for Rapid and Sensitive Detection of Bacteria with Olfactory Output},
  journal = {ACS NANO},
  year = {2017},
  volume = {11},
  number = {6},
  pages = {5339--5343},
  issn = {1936-0851},
  doi = {10.1021/acsnano.7b00822},
  url = {https://akademik.atauni.edu.tr/yayinlar/79092-sensing-by-smell-nanoparticle-enzyme-sensors-for-rapid-and-sensitive-detection}
}