Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I-II inhibition properties
Özet
The secondary sulfonamide derivatives containing benzothiazole scaffold (1-10) were synthesized to determine their inhibition properties on two physiologically essential human carbonic anhydrases isoforms (hCAs, EC, 4.2.1.1), hCA I, and hCA II. The inhibitory effects of the compounds on hCA I and hCA II isoenzymes were investigated by comparing their IC50 and Ki values. The Ki values of compounds (1-10) against hCA I and hCA II are in the range of 0.052 +/- 0.022-0.971 +/- 0.280 and 0.025 +/- 0.010-0.682 +/- 0.335, respectively. Some of these inhibited the enzyme more effectively than the standard drug, acetazolamide. In particular, compounds 5 and 4 were found to be most effective on hCA I and hCA II.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Öztürk, C., Kalay, E., Gerni, S., Balci, N., Tokali, F. S., Aslan, O. N., & Polat, E. (2024). Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I-II inhibition properties. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 71(1), 223–231. https://doi.org/10.1002/bab.2534
BibTeX
@article{ozturk2024-78782,
author = {Öztürk, Cansu and Kalay, Erbay and Gerni, Serpil and Balci, Neslihan and Tokali, Feyzi Sinan and Aslan, Osman Nuri and Polat, Emrah},
title = {Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I-II inhibition properties},
journal = {BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY},
year = {2024},
volume = {71},
number = {1},
pages = {223--231},
issn = {0885-4513},
doi = {10.1002/bab.2534},
url = {https://akademik.atauni.edu.tr/yayinlar/78782-sulfonamide-derivatives-with-benzothiazole-scaffold-synthesis-and-carbonic}
}