Synthesis and characterization of new cyclotriphosphazene compounds
Özet
In the present study, Spiro (1a), dispiro (1b, 2, 3), per-substituted spermine-bridged (6-9) and dispiroansa spermine (10) derivatives of cyclotriphosphazene have been synthesized. The structures of the novel compounds (1b, 6-10) have been characterized by elemental analysis, FTIR, mass spectrometry, H-1 and P-31 NMR spectroscopy. The molecular structures of 1b, 2, 8, and 10 were determined by single crystal X-ray crystallography. In order to investigate the anti-tumour properties of the newly synthesized cyclotriphosphazene derivatives, in vitro cytotoxic activity test (MTT assay) has been performed using HT-29 (human colon adenocarcinoma) and Hep2 (human epidermoid larynx carcinoma) cell lines. The result of the MU assay showed that while compound 1a has cytotoxic effect on both Hep2 and HT-29 cell lines, compound 3 has only cytotoxic effect towards the Hep 2 cells. (C) 2012 Elsevier Ltd. All rights reserved.
Anahtar kelimeler
Atıf için künye
YENİLMEZ ÇİFTÇİ, G., Tanrıverdi Eçik, E., YILDIRIM, T., YÜKSEL, F., BİLGİN, K., Şenkuytu, E., ULUDAĞ, Y., & KILIÇ, A. (2013). Synthesis and characterization of new cyclotriphosphazene compounds. TETRAHEDRON, 69(5), 1454–1461. https://doi.org/10.1016/j.tet.2012.12.027
BibTeX
@article{yenilmezciftci2013-78444,
author = {YENİLMEZ ÇİFTÇİ, GÖNÜL and Tanrıverdi Eçik, Esra and YILDIRIM, TUBA and YÜKSEL, FATMA and BİLGİN, KEMAL and Şenkuytu, Elif and ULUDAĞ, YILDIZ and KILIÇ, ADEM},
title = {Synthesis and characterization of new cyclotriphosphazene compounds},
journal = {TETRAHEDRON},
year = {2013},
volume = {69},
number = {5},
pages = {1454--1461},
issn = {0040-4020},
doi = {10.1016/j.tet.2012.12.027},
url = {https://akademik.atauni.edu.tr/yayinlar/78444-synthesis-and-characterization-of-new-cyclotriphosphazene-compounds}
}