Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents
Özet
In the present study, a number of new dispirobino and dispiroansa spermine derivatives of cyclotriphosphazene (8-10, 13) were synthesized and characterized by elemental analysis, mass spectrometry, H-1 and P-31 NMR spectroscopy. At first, in vitro cytotoxic activity of cyclotriphosphazene compounds (1-14) against HT-29 (human colon adenocarcinoma), Hep2 (Human epidermoid larynx carcinoma), and Vero (African green monkey kidney) cell lines was investigated. Our study showed that most of these compounds stimulate apoptosis and they have cytotoxic effects for HT-29 and Hep2 cells. Additionally, these compounds (1-14) were investigated for their antibacterial activity against gram-positive (Staphylococcus aureus), gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and for their antifungal activity against Candida albicans, and were shown to be inactive. (C) 2012 Elsevier Masson SAS. All rights reserved.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Yildirim, T., Bilgin, K., Çiftçi, G. Y., Tanrıverdi Eçik, E., Şenkuytu, E., Uludaǧ, Y., Tomak, L., & Kiliç, A. (2012). Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents. European journal of medicinal chemistry, 52, 213–220. https://doi.org/10.1016/j.ejmech.2012.03.018
BibTeX
@article{yildirim2012-78443,
author = {Yildirim, Tuba and Bilgin, Kemal and Çiftçi, Gönül Yenilmez and Tanrıverdi Eçik, Esra and Şenkuytu, Elif and Uludaǧ, Yildiz and Tomak, Leman and Kiliç, Adem},
title = {Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents},
journal = {European journal of medicinal chemistry},
year = {2012},
volume = {52},
pages = {213--220},
issn = {0223-5234},
doi = {10.1016/j.ejmech.2012.03.018},
url = {https://akademik.atauni.edu.tr/yayinlar/78443-synthesis-cytotoxicity-and-apoptosis-of-cyclotriphosphazene-compounds-as-anti}
}