Synthesis and Investigation of Anticancer Properties Fluoro Substitued BisChalcone Derivatives
Özet
The Claisen-Schmidt condensation reaction was used for the synthesis of bis-chalcone
derivatives. Reaction of ketone derivatives 2 and 11 with related aldehydes, bis-chalcone
derivatives were obtained. It is known that fluoro atom has positive effects on anticancer
activity, for this purpose especially fluoro substitued benzaldehyde derivatives was used. Four
new fluoro substituted bis-chalcone derivatives were synthesized and their anticancer activity
was determined against human colorectal adenocarcinoma cells (Caco-2), human breast
cancer cells (MDA-MB231), rattus pheochromocytoma (PC12) and mouse healthy fibroblast
cells (NIH3T3) and IC50 concentrations of the compounds, and cell viability was determined by
MTT assay.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Anıl, D., Özcan, Ş., Göbek, A., Cantürk, Z., Burmaoğlu, S., & Algül, Ö. (2020). Synthesis and Investigation of Anticancer Properties Fluoro Substitued BisChalcone Derivatives. 8. International Drug Chemistry Conference, Antalya (ss. 197–200).
BibTeX
@inproceedings{anil2020-78361,
author = {Anıl, Derya and Özcan, Şeyda and Göbek, Arzu and Cantürk, Zerrin and Burmaoğlu, Serdar and Algül, Öztekin},
title = {Synthesis and Investigation of Anticancer Properties Fluoro Substitued BisChalcone Derivatives},
booktitle = {8. International Drug Chemistry Conference},
address = {Antalya},
year = {2020},
pages = {197--200},
url = {https://akademik.atauni.edu.tr/yayinlar/78361-synthesis-and-investigation-of-anticancer-properties-fluoro-substitued}
}