Synthesis of 3,5-Diarylsubstituted İsoxazoles as an Anticancer Agent
Özet
In this work 3,5-diarylisoxazole derivatives was synthesized. The isoxazole precursor chalcone
compounds were obtained by the Claisen Schmidt condensation reaction. Later, these
chalcone derivatives were converted to isoxazole derivatives with TsNHOH reagent. Initially
investigated the effects of the 3,5-diarylisoxazole compounds proliferation capacity of PC3
cells as an in vitro cancer model and PNT1a cells as corresponding normal control cells.
Compound 26 distinguished from other compounds with a quite high specificity value that is
comparable to 5-FU.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Kaptan, Y., Anıl, D., Akınalp, G., Karataş, Ö. F., Burmaoğlu, S., & Algül, Ö. (2020). Synthesis of 3,5-Diarylsubstituted İsoxazoles as an Anticancer Agent. 8. International Drug Chemistry Conference, Antalya (ss. 201–205).
BibTeX
@inproceedings{kaptan2020-78359,
author = {Kaptan, Yakup and Anıl, Derya and Akınalp, Gökçen and Karataş, Ömer Faruk and Burmaoğlu, Serdar and Algül, Öztekin},
title = {Synthesis of 3,5-Diarylsubstituted İsoxazoles as an Anticancer Agent},
booktitle = {8. International Drug Chemistry Conference},
address = {Antalya},
year = {2020},
pages = {201--205},
url = {https://akademik.atauni.edu.tr/yayinlar/78359-synthesis-of-35-diarylsubstituted-isoxazoles-as-an-anticancer-agent}
}