Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents
Özet
The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H-1 NMR, C-13 NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
-
SKA 3: Sağlıklı Bireyler
Atıf için künye
Anıl, D., Akinalp, G., Sanli, F., Yucel, M. A., Gambacorta, N., Nicolotti, O., Karatas, O. F., Algul, O., & Burmaoğlu, S. (2020). Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 30. https://doi.org/10.1016/j.bmcl.2020.127427
BibTeX
@article{anil2020-78349,
author = {Anıl, Derya and Akinalp, Gökçen and Sanli, Fatma and Yucel, Mehmet Ali and Gambacorta, Nicola and Nicolotti, Orazio and Karatas, Omer Faruk and Algul, Oztekin and Burmaoğlu, Serdar},
title = {Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents},
journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS},
year = {2020},
volume = {30},
issn = {0960-894X},
doi = {10.1016/j.bmcl.2020.127427},
url = {https://akademik.atauni.edu.tr/yayinlar/78349-design-synthesis-and-biological-evaluation-of-35-diaryl-isoxazole-derivatives-as}
}