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Makale Tam Makale Uluslararası 2021

Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties

Elcin Cagatay, Volkan Akyıldız, Yavuz Ergun, HÜLYA AYAR KAYALI

CHEMISTRY AND BIODIVERSITY Cilt 18 · Sayı 11 · 01.11.2021
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Özet

A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.

Anahtar kelimeler

oxidative stress CANCER apoptosis cytotoxicity Hydrogen peroxide BINDING DEATH CELL-CYCLE ARREST murrayaquinone A organic synthesis anti-tumor activity colon cancer cell lines SERUM-ALBUMIN CARBAZOLEQUINONES

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Cagatay, E., Akyıldız, V., Ergun, Y., & AYAR KAYALI, H. (2021). Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties. CHEMISTRY AND BIODIVERSITY, 18(11). https://doi.org/10.1002/cbdv.202100348

BibTeX 
@article{cagatay2021-78135,
  author = {Cagatay, Elcin and Akyıldız, Volkan and Ergun, Yavuz and AYAR KAYALI, HÜLYA},
  title = {Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties},
  journal = {CHEMISTRY AND BIODIVERSITY},
  year = {2021},
  volume = {18},
  number = {11},
  issn = {1612-1872},
  doi = {10.1002/cbdv.202100348},
  url = {https://akademik.atauni.edu.tr/yayinlar/78135-synthesis-of-murrayaquinone-a-derivatives-and-investigation-of-potential}
}