Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives
Özet
Nowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 mu g/plate concentrations.
Anahtar kelimeler
Atıf için künye
Özkan, H., Gültekin, D., SEZEN, S., Ozgeris, B., GÜLLÜCE, M., & Tumer, F. (2015). Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives. TOXICOLOGY AND INDUSTRIAL HEALTH, 31(12), 1252–1257. https://doi.org/10.1177/0748233713491810
BibTeX
@article{ozkan2015-77408,
author = {Özkan, Hakan and Gültekin, Demet and SEZEN, Selma and Ozgeris, Bunyamin and GÜLLÜCE, Medine and Tumer, Ferhan},
title = {Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives},
journal = {TOXICOLOGY AND INDUSTRIAL HEALTH},
year = {2015},
volume = {31},
number = {12},
pages = {1252--1257},
issn = {0748-2337},
doi = {10.1177/0748233713491810},
url = {https://akademik.atauni.edu.tr/yayinlar/77408-mutagenic-assessment-of-three-synthetic-pyridine-diaryl-ketone-derivatives}
}