Synthesis of dipyrrolo-diazepine derivatives via intramolecular alkyne cyclization

Baskin, Dilges; Çetinkaya, Yasin; Balci, Metin

doi:10.1016/j.tet.2018.06.013

Makale Tam Makale Uluslararası 2018

Synthesis of dipyrrolo-diazepine derivatives via intramolecular alkyne cyclization

Dilges Baskin, Yasin Çetinkaya, Metin Balci

TETRAHEDRON Cilt 74 · Sayı 30 · ss. 4062–4070 · 26.07.2018

DOI ile aç

Özet

A regioselective approach was developed for the synthesis of dipyrrolo-diazepine derivatives. The synthetic route to dipyrrolo-diazepines first involves the synthesis of dipyrromethanes, followed by reaction of propargyl bromide in the presence of NaH to attach one alkyne functionality to the pyrrole nitrogen atom. Intramolecular heterocyclization with NaH in DMF between the alkyne functionality and pyrrole nitrogen atom gave the desired structures in good yields. (C) 2018 Elsevier Ltd. All rights reserved.

Anahtar kelimeler

Indole pyrrole Alkyne cyclization Dipyrromethane Diazepine

Atıf için künye

Baskin, D., Çetinkaya, Y., & Balci, M. (2018). Synthesis of dipyrrolo-diazepine derivatives via intramolecular alkyne cyclization. TETRAHEDRON, 74(30), 4062–4070. https://doi.org/10.1016/j.tet.2018.06.013

BibTeX

@article{baskin2018-76385,
  author = {Baskin, Dilges and Çetinkaya, Yasin and Balci, Metin},
  title = {Synthesis of dipyrrolo-diazepine derivatives via intramolecular alkyne cyclization},
  journal = {TETRAHEDRON},
  year = {2018},
  volume = {74},
  number = {30},
  pages = {4062--4070},
  issn = {0040-4020},
  doi = {10.1016/j.tet.2018.06.013},
  url = {https://akademik.atauni.edu.tr/yayinlar/76385-synthesis-of-dipyrrolo-diazepine-derivatives-via-intramolecular-alkyne}
}