The protective effect of the cardiac thioredoxin system on the heart in the case of iron overload in mice.
Özet
Background: Iron, which is essential for many vital biological processes, causes significant clinical pathologies in the case of its deficiency or excess. Cardiovascular protective pathways are activated by iron therapy. However, determining the appropriate iron concentration is essential to protect heart tissue from iron-induced oxidative stress. The thioredoxin system is one of the antioxidant systems that protect cells against oxidative stress. Moreover, it allows the binding of many transcription factors for apoptosis, myocardial protection, the stimulation of cell proliferation, and angiogenesis processes, especially the regulation of the cardiovascular system. This study's goal was to understand how iron overload affects the gene and protein levels of the thioredoxin system in the mouse heart.
Anahtar kelimeler
Atıf için künye
Altun, S., & Budak, H. (2021). The protective effect of the cardiac thioredoxin system on the heart in the case of iron overload in mice. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 64. https://doi.org/10.1016/j.jtemb.2020.126704
BibTeX
@article{altun2021-75654,
author = {Altun, Sevda and Budak, Harun},
title = {The protective effect of the cardiac thioredoxin system on the heart in the case of iron overload in mice.},
journal = {JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY},
year = {2021},
volume = {64},
issn = {0946-672X},
doi = {10.1016/j.jtemb.2020.126704},
url = {https://akademik.atauni.edu.tr/yayinlar/75654-the-protective-effect-of-the-cardiac-thioredoxin-system-on-the-heart-in-the-case}
}