Lichen Acids May Be Used as A Potential Drug For Cancer Therapy; by Inhibiting Mitochondrial Thioredoxin Reductase Purified From Rat Lung
Özet
Background: Thioredoxin reductase (E.C 1.6.4.5.; TrxR) is a widely distributed flavoprotein that catalyzes the NAI)PH-dependent reduction of thioredoxin (Trx) in many cellular events such as DNA synthesis. DNA repair, angiogenesis, antioxidative defense, and regulating apoptosis. Although TrxR is indispensible in protecting cells against oxidative stress, the overexpression of TrxR is seen in many aggressive tumors. Therefore, targeted inhibition of TrxR has been accepted as a new approach for chemotherapy.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Özgençli, I., Budak, H., Ciftci, M., & Anar, M. (2018). Lichen Acids May Be Used as A Potential Drug For Cancer Therapy; by Inhibiting Mitochondrial Thioredoxin Reductase Purified From Rat Lung. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 18(11), 1599–1605. https://doi.org/10.2174/1871520618666180525095520
BibTeX
@article{ozgencli2018-75646,
author = {Özgençli, Ilknur and Budak, Harun and Ciftci, Mehmet and Anar, Mustafa},
title = {Lichen Acids May Be Used as A Potential Drug For Cancer Therapy; by Inhibiting Mitochondrial Thioredoxin Reductase Purified From Rat Lung},
journal = {ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY},
year = {2018},
volume = {18},
number = {11},
pages = {1599--1605},
issn = {1871-5206},
doi = {10.2174/1871520618666180525095520},
url = {https://akademik.atauni.edu.tr/yayinlar/75646-lichen-acids-may-be-used-as-a-potential-drug-for-cancer-therapy-by-inhibiting}
}