Evaluation of Oxidative Stress: İmpact of Bromelain in Hyperlipidemic Wistar rats

In our study, the effect of Bromelain on the histopathological changes in the kidney tissue of hyperlipidemic rats induced

by an artificial surfactant, Tyloxopol, was evaluated. For the analysis, 18 Wistar rats (Rattus norvecigus, male) weighing

250±30 g were used. Experimental animals were randomly divided into three groups (n=6) and caged. Group A: Healthy

control, Group B; Hyperlipidemic control group (a single dose of Tyloxapol (400 mg/kg, i.p) administered 24 hours before

bromelain administration) and Group C: Tyloxapol + Bromelain group (bromelain (250 mg/kg, daily for 18 days) orally

for 18 days after 24 hours of bromelain administration) ) were classified as the given group. For histopathological

examinations, kidney tissues taken from rats 24 hours after the applications were taken into the pathological process and

made ready for microscopic examination. While no pathological findings were observed in the healthy control group in

the imaging process, pathological changes such as tubular dilatation, congestion, bleeding, mononuclear cell infiltration,

apoptosis and necrosis in the cells were observed in the hyperlipidemia group. The pathological findings that emerged

with the application of bromelain were reduced by the effect of bromelain.

As a result of the examinations, it has been clearly stated that bromelain has a protective effect against the damage to the

kidney tissue caused by hyperlipidemia.