Impact of long term Fe3+ toxicity on expression of glutathione system in rat liver

Budak, Harun; Gönül Baltacı, Nurdan; Ceylan, Hamid; KOCPINAR, EF

doi:10.1016/j.etap.2013.12.007

Makale Tam Makale Uluslararası 2014

Impact of long term Fe3+ toxicity on expression of glutathione system in rat liver

Harun Budak, Nurdan Gönül Baltacı, Hamid Ceylan, EF KOCPINAR

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY Sayı 1 · ss. 365–370 · 01.01.2014

DOI ile aç

Özet

The free radicals within the body, produced by metabolic activities or derived from environmental sources are relatively related to hepatoxicity. Since heavy metals including iron have the ability to produce free radicals, the liver glutathione system neutralizes them to protect cells against any damage. The objective of this study is to indicate the toxic effects of iron on the glutathione system at the enzymatic and molecular level. Thus, any possible correlation between enzymatic and molecular levels can be determined. According to our results, while mRNA expression of glutathione reductase (Gsr) and glutathione S-transferases (Gsta5) genes were not affected by long-term exposure to various concentrations of iron (Fe3+), transcription level of glutathione peroxidase (Gpx2) was influenced in the presence of toxic iron. Whereas the enzyme activites of GSR (GR), GPX and GST were significantly affected in rat liver. (C) 2013 Elsevier B.V. All rights reserved.

Anahtar kelimeler

MECHANISMS IRON-DEFICIENCY ANEMIA ENZYME-ACTIVITY METABOLISM MAMMARY-GLAND INDUCED OXIDATIVE STRESS IRON LEAD Toxic effects mRNA expression GLUTATHIONE SYSTEM CANCER-RISK S-TRANSFERASE DIETARY IRON OVERLOAD

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Budak, H., Gönül Baltacı, N., Ceylan, H., & KOCPINAR, E. (2014). Impact of long term Fe3+ toxicity on expression of glutathione system in rat liver. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY(1), 365–370. https://doi.org/10.1016/j.etap.2013.12.007

BibTeX

@article{budak2014-74964,
  author = {Budak, Harun and Gönül Baltacı, Nurdan and Ceylan, Hamid and KOCPINAR, EF},
  title = {Impact of long term Fe3+ toxicity on expression of glutathione system in rat liver},
  journal = {ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY},
  year = {2014},
  number = {1},
  pages = {365--370},
  issn = {1382-6689},
  doi = {10.1016/j.etap.2013.12.007},
  url = {https://akademik.atauni.edu.tr/yayinlar/74964-impact-of-long-term-fe3-toxicity-on-expression-of-glutathione-system-in-rat}
}