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Makale Tam Makale Uluslararası 2022

Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes

Yeliz Demir, Hamid Ceylan, Cüneyt Türkeş, Şükrü Beydemir

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS Cilt 40 · Sayı 22 · ss. 12008–12021 · 01.01.2022
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Özet

Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and SDH enzymes were determined. These enzymes inhibition could be essential to prevent diabetic complications. AR and SDH enzymes were purified from sheep kidney. Then, VA, CA and UA were tested in various concentrations against these enzymes activity in vitro. K-I values were found to be as 1.46 +/- 0.04, 5.13 +/- 0.25 and 11.71 +/- 0.27 mu M for VA, CA and UA, respectively, for AR. K-I constants were found to be as 15.32 +/- 0.34, 145.60 +/- 2.17 and 213.40 +/- 2.64 mu M VA, CA and UA, respectively, for SDH. These findings indicate that VA, CA and UA could be useful in the treatment of diabetic complications. Communicated by Ramaswamy H. Sarma

Anahtar kelimeler

DESIGN DERIVATIVES VITRO Calcium channel blockers usnic acid COMPLEXES HYDROCHLORIDE aldose reductase POTENTIAL ACETYLCHOLINESTERASE Sorbitol dehydrogenase carnosic acid vulpinic acid IN-SILICO EVALUATION NONCLASSICAL CARBONIC-ANHYDRASE GLYCATION

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Demir, Y., Ceylan, H., Türkeş, C., & Beydemir, Ş. (2022). Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 40(22), 12008–12021. https://doi.org/10.1080/07391102.2021.1967195

BibTeX 
@article{demir2022-74931,
  author = {Demir, Yeliz and Ceylan, Hamid and Türkeş, Cüneyt and Beydemir, Şükrü},
  title = {Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes},
  journal = {JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS},
  year = {2022},
  volume = {40},
  number = {22},
  pages = {12008--12021},
  issn = {0739-1102},
  doi = {10.1080/07391102.2021.1967195},
  url = {https://akademik.atauni.edu.tr/yayinlar/74931-molecular-docking-and-inhibition-studies-of-vulpinic-carnosic-and-usnic-acids-on}
}