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Makale Tam Makale Uluslararası 2017

Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins

BÜNYAMİN ÖZGERİŞ, YUSUF AKBABA, Hasan Türkez, HASAN TÜRKEZ, Süleyman Göksu

ARCHIVES OF MEDICAL RESEARCH Cilt 48 · Sayı 6 · ss. 513–519 · 01.08.2017
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Özet

Background and Aims. In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays.

Anahtar kelimeler

ASSAY DERIVATIVES ANALOGS ANTICANCER ACTIVITY urea sulfamide ANHYDRASE INHIBITORY PROPERTIES Aminotetralin CYTO-TOXICITY PC-3 cell line U-87MG cell line

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

ÖZGERİŞ, B., AKBABA, Y., Türkez, H., TÜRKEZ, H., & Göksu, S. (2017). Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins. ARCHIVES OF MEDICAL RESEARCH, 48(6), 513–519. https://doi.org/10.1016/j.arcmed.2017.12.002

BibTeX 
@article{ozgeris2017-72150,
  author = {ÖZGERİŞ, BÜNYAMİN and AKBABA, YUSUF and Türkez, Hasan and TÜRKEZ, HASAN and Göksu, Süleyman},
  title = {Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins},
  journal = {ARCHIVES OF MEDICAL RESEARCH},
  year = {2017},
  volume = {48},
  number = {6},
  pages = {513--519},
  issn = {0188-4409},
  doi = {10.1016/j.arcmed.2017.12.002},
  url = {https://akademik.atauni.edu.tr/yayinlar/72150-synthesis-and-anticancer-activity-of-novel-ureas-and-sulfamides-incorporating-1}
}