Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
Özet
Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9, 10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).
Anahtar kelimeler
Atıf için künye
Burmaoğlu, S., Secinti, H., Mozioglu, E., Goren, A. C., Altundas, R., & Seçen, H. (2017). Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 32(1), 878–884. https://doi.org/10.1080/14756366.2017.1337758
BibTeX
@article{burmaoglu2017-71407,
author = {Burmaoğlu, Serdar and Secinti, Hatice and Mozioglu, Erkan and Goren, Ahmet C. and Altundas, Ramazan and Seçen, Hasan},
title = {Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2017},
volume = {32},
number = {1},
pages = {878--884},
issn = {1475-6366},
doi = {10.1080/14756366.2017.1337758},
url = {https://akademik.atauni.edu.tr/yayinlar/71407-syntheses-and-evaluation-of-multicaulin-and-miltirone-like-compounds-as}
}