Makale
Tam Makale
Uluslararası
2017
Synthesis of C-13 labeled beta-cyano-L-alanine Nesa Ghasemi and Hasan Secen
Organic Communications
Cilt 10 · Sayı 1 · ss. 6–10 · 01.01.2017
Özet
A synthetic methodology for preparation of beta-cyano-L-alanine was developed via L-serine. Esterification of L -serine with MeOH, followed by protection of NH2 with CBz, gave methyl 2-(benzyloxycarbonylamino)-3-hydroxypropanoate. Mesylation of OH group, and then cyanation, ester hydrolysis and removal of the CBz group with catalytic hydrogenation, gave beta-cyano-L-alanine. Crucial step for the synthesis of the title compound was cyanation with (KCN)-C-13.
Atıf için künye
GHASEMI, N., & Seçen, H. (2017). Synthesis of C-13 labeled beta-cyano-L-alanine Nesa Ghasemi and Hasan Secen. Organic Communications, 10(1), 6–10. https://doi.org/10.25135/acg.oc.2.16.08.502
BibTeX
@article{ghasemi2017-71400,
author = {GHASEMI, NESA and Seçen, Hasan},
title = {Synthesis of C-13 labeled beta-cyano-L-alanine Nesa Ghasemi and Hasan Secen},
journal = {Organic Communications},
year = {2017},
volume = {10},
number = {1},
pages = {6--10},
issn = {1307-6175},
doi = {10.25135/acg.oc.2.16.08.502},
url = {https://akademik.atauni.edu.tr/yayinlar/71400-synthesis-of-c-13-labeled-beta-cyano-l-alanine-nesa-ghasemi-and-hasan-secen}
}