Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line
Özet
Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.
Anahtar kelimeler
Atıf için künye
Tuncay, S., ŞENOL, H., GÜLER, E. M., Ocal, N., Seçen, H., KOÇYİĞİT, A., & TOPÇU, G. (2018). Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line. MEDICINAL CHEMISTRY, 14(6), 617–625. https://doi.org/10.2174/1573406414666180222094544
BibTeX
@article{tuncay2018-71396,
author = {Tuncay, Salih and ŞENOL, HALİL and GÜLER, Eray Metin and Ocal, Nuket and Seçen, Hasan and KOÇYİĞİT, ABDÜRRAHİM and TOPÇU, GÜLAÇTI},
title = {Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line},
journal = {MEDICINAL CHEMISTRY},
year = {2018},
volume = {14},
number = {6},
pages = {617--625},
issn = {1573-4064},
doi = {10.2174/1573406414666180222094544},
url = {https://akademik.atauni.edu.tr/yayinlar/71396-synthesis-of-oleanolic-acid-analogues-and-their-cytotoxic-effects-on-3t3-cell}
}