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Makale Tam Makale Uluslararası 2011

Alternative and Straightforward Synthesis of Dopaminergic 5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Necla OZTASKIN, Süleyman Göksu, Hasan Seçen

SYNTHETIC COMMUNICATIONS Cilt 41 · Sayı 13 · ss. 2017–2024 · 01.01.2011
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Özet

[image omitted] 5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine was synthesized from 2-naphthoic acid in six steps with an overall yield of 27%. Following the reaction sequence, bromination, esterification, substitution with NaOMe in the presence of CuI, the Birch reduction, Curtius rearrangement, and hydrogenolysis afforded biologically active title compound 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine as hydrogen chloride salt.

Anahtar kelimeler

Synthesis DOPAMINE Curtius rearrangement Aminotetralin Birch reduction neurotransmitter

Atıf için künye

OZTASKIN, N., Göksu, S., & Seçen, H. (2011). Alternative and Straightforward Synthesis of Dopaminergic 5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine. SYNTHETIC COMMUNICATIONS, 41(13), 2017–2024. https://doi.org/10.1080/00397911.2010.495043

BibTeX 
@article{oztaskin2011-71385,
  author = {OZTASKIN, Necla and Göksu, Süleyman and Seçen, Hasan},
  title = {Alternative and Straightforward Synthesis of Dopaminergic 5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine},
  journal = {SYNTHETIC COMMUNICATIONS},
  year = {2011},
  volume = {41},
  number = {13},
  pages = {2017--2024},
  issn = {0039-7911},
  doi = {10.1080/00397911.2010.495043},
  url = {https://akademik.atauni.edu.tr/yayinlar/71385-alternative-and-straightforward-synthesis-of-dopaminergic-5-methoxy-1234}
}