Two efficient methods for the total synthesis of the natural diarylheptanoid 7-(4-hydroxyphenyl)-1-phenylheptan-3-one

Diarylheptanoids are compounds with an ArC7Ar structure, where two aromatic rings are connected by a seven-carbon chain. To date, over 500 structurally diverse diarylheptanoids have been isolated from nature. These compounds are generally minor secondary metabolites found in plants. Natural diarylheptanoids possess a wide range of biological activities, making their short and efficient total synthesis important for enabling further research on these substances. In this study, two efficient synthesis methods developed for the compound 7-(4-hydroxyphenyl)-1phenylheptan-3-one, which is isolated as a minor component from Alpinia officinarum, are presented.