Synthesis and biological evaluation of (S)-4-aminoquinazoline alcohols
Özet
A simple synthetic method for the preparation of enantiomerically pure (S)-4-aminoquinazoline alcohols from (S)-quinazolinone alcohols by key steps including chlorination, nucleophilic ipso substitution, and deacetylation is presented. Mutagenic and antimutagenic properties of the (S)-4-aminoquinazoline alcohols were investigated by using Salmonella typhimurium TA1535, and Escherichia colt WP2uvrA tester strains at 0.01, 0.1, and 1 mu g/plate concentrations. (S)-4-aminoquinazoline alcohols were found to be genotoxically safe at the tested concentrations. Among the tested (S)-4-aminoquinazoline alcohols, the best antimutagenic activity was obtained with a methyl derivative at 0.1 mu g/plate dose. (C) 2010 Elsevier Ltd. All rights reserved.
Atıf için künye
Çakıcı, M., Catir, M., Karabuga, S., Kılıç, H., Ulukanli, S., GÜLLÜCE, M., & ORHAN, F. (2010). Synthesis and biological evaluation of (S)-4-aminoquinazoline alcohols. TETRAHEDRON-ASYMMETRY, 21(16), 2027–2031. https://doi.org/10.1016/j.tetasy.2010.05.040
BibTeX
@article{cakici2010-71191,
author = {Çakıcı, Murat and Catir, Mustafa and Karabuga, Semistan and Kılıç, Hamdullah and Ulukanli, Sabri and GÜLLÜCE, Medine and ORHAN, Furkan},
title = {Synthesis and biological evaluation of (S)-4-aminoquinazoline alcohols},
journal = {TETRAHEDRON-ASYMMETRY},
year = {2010},
volume = {21},
number = {16},
pages = {2027--2031},
issn = {0957-4166},
doi = {10.1016/j.tetasy.2010.05.040},
url = {https://akademik.atauni.edu.tr/yayinlar/71191-synthesis-and-biological-evaluation-of-s-4-aminoquinazoline-alcohols}
}