Trapping of Organophosphorus Chemical Nerve Agents in Water with Amino Acid Functionalized Baskets
Özet
We prepared eleven amino-acid functionalized baskets and used H-1 NMR spectroscopy to quantify their affinity for entrapping dimethyl methylphosphonate (DMMP, 118 angstrom(3)) in aqueous phosphate buffer at pH=7.0 +/- 0.1; note that DMMP guest is akin in size to chemical nerve agent sarin (132 angstrom(3)). The binding interaction (K-a) was found to vary with the size of substituent groups at the baskets rim. In particular, the degree of branching at the first carbon of each substituent had the greatest effect on the host-guest interaction, as described with the Verloops B1 steric parameter. The branching at the remote carbons, however, did not perturb the encapsulation, which is important for guiding the design of more effective hosts and catalysts in future.
Anahtar kelimeler
Atıf için künye
Ruan, Y., DALKILIC, E., Peterson, P. W., Pandit, A., Daştan, A., Brown, J. D., Polen, S. M., Hadad, C. M., & Badjic, J. D. (2014). Trapping of Organophosphorus Chemical Nerve Agents in Water with Amino Acid Functionalized Baskets. Chemistry - A European Journal, 20(15), 4251–4256. https://doi.org/10.1002/chem.201304779
BibTeX
@article{ruan2014-70680,
author = {Ruan, Yian and DALKILIC, Erdin and Peterson, Paul W. and Pandit, Aroh and Daştan, Arif and Brown, Jason D. and Polen, Shane M. and Hadad, Christopher M. and Badjic, Jovica D.},
title = {Trapping of Organophosphorus Chemical Nerve Agents in Water with Amino Acid Functionalized Baskets},
journal = {Chemistry - A European Journal},
year = {2014},
volume = {20},
number = {15},
pages = {4251--4256},
issn = {0947-6539},
doi = {10.1002/chem.201304779},
url = {https://akademik.atauni.edu.tr/yayinlar/70680-trapping-of-organophosphorus-chemical-nerve-agents-in-water-with-amino-acid}
}