In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates
Özet
Glutathione reductase (GR), is responsible for the existence of GSH molecule, a crucial antioxidant against oxidative stress reagents. The antimalarial activities of some redox active compounds are attributed to their inhibition of antioxidant flavoenzyme glutathione reductase, and inhibitors are therefore expected to be useful for the treatment of malaria. Twelve organic nitrate derivatives were synthesized and treated with human erythrocyte GR. The molecules were identified as strong GR inhibitors and novel antimalaria candidates. (C) 2009 Elsevier Ltd. All rights reserved.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
SENTURK, M., TALAZ, O., EKINCI, D., CAVDAR, H., & Küfrevioğlu, Ö. İ. (2009). In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(13), 3661–3663. https://doi.org/10.1016/j.bmcl.2009.04.087
BibTeX
@article{senturk2009-68804,
author = {SENTURK, Murat and TALAZ, Oktay and EKINCI, Deniz and CAVDAR, Hueseyin and Küfrevioğlu, Ömer İrfan},
title = {In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates},
journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS},
year = {2009},
volume = {19},
number = {13},
pages = {3661--3663},
issn = {0960-894X},
doi = {10.1016/j.bmcl.2009.04.087},
url = {https://akademik.atauni.edu.tr/yayinlar/68804-in-vitro-inhibition-of-human-erythrocyte-glutathione-reductase-by-some-new}
}