Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors

ARSLAN, O; Küfrevioğlu, Ömer İrfan; NALBANTOGLU, B

doi:10.1016/s0968-0896(96)00272-6

Makale Tam Makale Uluslararası 1997

Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors

O ARSLAN, Ömer İrfan Küfrevioğlu, B NALBANTOGLU

BIOORGANIC & MEDICINAL CHEMISTRY Cilt 5 · Sayı 3 · ss. 515–518 · 01.03.1997

DOI ile aç

Özet

Three new derivatives of 2-substituted 1,3,4-thiadiazole-5-sulfonamide have been synthesized. These compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide (1); 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide (2); and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide (3). Inhibition effects of these compounds on carbonic anhydrase I and II have been investigated. By comparing I-50 and K-i values of the compounds, it has been found that compound 1 is a more potent inhibitor than acetazolamide (b) on carbonic anhydrase II. (C) 1997 Elsevier Science Ltd.

Anahtar kelimeler

Pressure BINDING CARBONIC-ANHYDRASE INHIBITORS CO2 carbonic anhydrase isozymes OCULAR PHARMACOLOGY EYE

Atıf için künye

ARSLAN, O., Küfrevioğlu, Ö. İ., & NALBANTOGLU, B. (1997). Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, 5(3), 515–518. https://doi.org/10.1016/s0968-0896%2896%2900272-6

BibTeX

@article{arslan1997-68768,
  author = {ARSLAN, O and Küfrevioğlu, Ömer İrfan and NALBANTOGLU, B},
  title = {Synthesis and investigation of inhibition effects of new carbonic anhydrase inhibitors},
  journal = {BIOORGANIC & MEDICINAL CHEMISTRY},
  year = {1997},
  volume = {5},
  number = {3},
  pages = {515--518},
  issn = {0968-0896},
  doi = {10.1016/s0968-0896(96)00272-6},
  url = {https://akademik.atauni.edu.tr/yayinlar/68768-synthesis-and-investigation-of-inhibition-effects-of-new-carbonic-anhydrase}
}