Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.
Özet
The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and human serum isozyme VI, with a series of tosylited aromatic amine derivatives was investigated. The K-I ranges of compounds 1-14 and acetazolamide against hCA I ranged between 1.130 and- 448.2 mu M, against hCA II between 0.103 and- 14.3 mu M, and against hCA VI ranged between 0.340 and- 42.39 mu M. Tosylited aromatic amine derivatives are thus interesting hCA I, II and VI inhibitors, and might be used as leads for generating enzyme inhibitors eventually targeting other isoforms which have not been assayed yet for their interactions with such agents.
Anahtar kelimeler
Atıf için künye
ALP, C., OZSOY, S., ALP, N. A., Kılıç, D., Gültekin, M. S., Küfrevioğlu, Ö. İ., Senturk, M., & SUPURAN, C. T. (2012). Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 27(6), 818. https://doi.org/10.3109/14756366.2011.617745
BibTeX
@article{alp2012-68724,
author = {ALP, Cemalettin and OZSOY, Seyda and ALP, Nurdan Alcan and Kılıç, Deryanur and Gültekin, Mehmet Serdar and Küfrevioğlu, Ömer İrfan and Senturk, Murat and SUPURAN, Claudiu T.},
title = {Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2012},
volume = {27},
number = {6},
pages = {818},
issn = {1475-6366},
doi = {10.3109/14756366.2011.617745},
url = {https://akademik.atauni.edu.tr/yayinlar/68724-sulfapyridine-like-benzenesulfonamide-derivatives-as-inhibitors-of-carbonic}
}