A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver
Özet
Background: While Thioredoxin Reductase (TrxR) plays an important role in regulation of the intracellular redox balance and various signalling pathways, Glutathione S-Transferase (GSTs) enzymes belong to the detoxification family that catalyse the conjugation of glutathione with various endogenous and xenobiotic electrophiles. Since TrxR and GSTs are overexpressed in many cancer cells, they have been identified as potential targets to develop chemotherapeutic strategies.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Özgençli, I., Kılıç, D., Guller, U., Ciftci, M., Küfrevioğlu, Ö. İ., & Budak, H. (2018). A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 18(14), 2053–2061. https://doi.org/10.2174/1871520618666180910093335
BibTeX
@article{ozgencli2018-68684,
author = {Özgençli, Ilknur and Kılıç, Deryanur and Guller, Ugur and Ciftci, Mehmet and Küfrevioğlu, Ömer İrfan and Budak, Harun},
title = {A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver},
journal = {ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY},
year = {2018},
volume = {18},
number = {14},
pages = {2053--2061},
issn = {1871-5206},
doi = {10.2174/1871520618666180910093335},
url = {https://akademik.atauni.edu.tr/yayinlar/68684-a-comparison-of-the-inhibitory-effects-of-anti-cancer-drugs-on-thioredoxin}
}