In vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compounds

Sarikaya, Sevim Beyza Ozturk; TOPAL, Fevzi; Senturk, Murat; Gülçin, İlhami; SUPURAN, Claudiu T.

doi:10.1016/j.bmcl.2011.05.071

Makale Tam Makale Uluslararası 2011

In vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compounds

Sevim Beyza Ozturk Sarikaya, Fevzi TOPAL, Murat Senturk, İlhami Gülçin, Claudiu T. SUPURAN

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Cilt 21 · Sayı 14 · ss. 4259–4262 · 15.07.2011

DOI ile aç

Özet

Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against three human CA isozymes (hCA I, hCA II, and hCA VI) and the gill carbonic anhydrase of the teleost fish Dicentrarchus labrax (European seabass) (dCA). The isozymes showed quite diverse inhibition profiles with these compounds. These data may lead to design novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.

Anahtar kelimeler

carbonic anhydrase INHIBITION DRUGS THERAPEUTIC APPLICATIONS BINDING HCA I SULFONAMIDES hCA II ACTIVATORS Tannic acid METAL-COMPLEXES ESTERASE-ACTIVITIES THIOXOLONE antiglaucoma Pyrogallol hCA VI dCA ERYTHROCYTE GLUTATHIONE-REDUCTASE VI

Sürdürülebilir Kalkınma Amaçları

SKA 15: Karasal Yaşam

Atıf için künye

Sarikaya, S. B. O., TOPAL, F., Senturk, M., Gülçin, İ., & SUPURAN, C. T. (2011). In vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compounds. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(14), 4259–4262. https://doi.org/10.1016/j.bmcl.2011.05.071

BibTeX

@article{sarikaya2011-68091,
  author = {Sarikaya, Sevim Beyza Ozturk and TOPAL, Fevzi and Senturk, Murat and Gülçin, İlhami and SUPURAN, Claudiu T.},
  title = {In vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compounds},
  journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS},
  year = {2011},
  volume = {21},
  number = {14},
  pages = {4259--4262},
  issn = {0960-894X},
  doi = {10.1016/j.bmcl.2011.05.071},
  url = {https://akademik.atauni.edu.tr/yayinlar/68091-in-vitro-inhibition-of-alpha-carbonic-anhydrase-isozymes-by-some-phenolic}
}