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Makale Tam Makale Uluslararası 2016

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

Fazile Nur Ekinci Akdemir, İlhami Gülçin, Berna Karagoz, Recep Soslu, Saleh H. ALWASEL

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Cilt 31 · ss. 114–118 · 01.01.2016
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Özet

The antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA+I/R group. HES (100 mg/kg) has been given orally in the HES+1/R group. The left gastrocnemius muscle has been harvested and stored immediately at -80 degrees C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p<0.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p<0.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA+I/R and HES+I/R groups.

Anahtar kelimeler

ANTIOXIDANT ACTIVITY ISCHEMIA-REPERFUSION INJURY phenolic compounds hesperidin INDUCED OXIDATIVE STRESS SKELETAL-MUSCLE ELLAGIC ACID IN-VITRO ANTIOXIDANT POLYPHENOL CONTENTS CAFFEIC ACID RADICAL SCAVENGING ACTIVITIES LYOPHILIZED AQUEOUS EXTRACT ANTIRADICAL ACTIVITIES LUNG CARCINOGENESIS

Atıf için künye

Akdemir, F. N. E., Gülçin, İ., Karagoz, B., Soslu, R., & ALWASEL, S. H. (2016). A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31, 114–118. https://doi.org/10.1080/14756366.2016.1220378

BibTeX 
@article{akdemir2016-68089,
  author = {Akdemir, Fazile Nur Ekinci and Gülçin, İlhami and Karagoz, Berna and Soslu, Recep and ALWASEL, Saleh H.},
  title = {A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury},
  journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
  year = {2016},
  volume = {31},
  pages = {114--118},
  issn = {1475-6366},
  doi = {10.1080/14756366.2016.1220378},
  url = {https://akademik.atauni.edu.tr/yayinlar/68089-a-comparative-study-on-the-antioxidant-effects-of-hesperidin-and-ellagic-acid}
}