Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase enzymes inhibitors: The novel N,N '-bis-cyanomethylamine and alkoxymethylamine derivatives
Özet
During this investigation, N,N'-bis-azidomethylamines, N,N'-bis-cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to be a new generation of multifunctional compounds, were synthesized, functional properties were investigated, and anticholinergic and antidiabetic properties of those compounds were studied through the laboratory tests, and it was approved that they contain physiologically active compounds rather than analogues. Novel N-bis-cyanomethylamine and alkoxymethylamine derivatives were effective inhibitors of the alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with K-i values in the range of 0.15-13.31 nM for alpha-glycosidase, 2.77-15.30 nM for human carbonic anhydrase isoenzymes I (hCA I), 3.12-21.90 nM for human carbonic anhydrase isoenzymes II (hCA II), 23.33-73.23 nM for AChE, and 3.84-48.41 nM for BChE, respectively. Indeed, the inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances.
Anahtar kelimeler
Atıf için künye
TASLIMI, P., Caglayan, C., Farzaliyev, V., Nabiyev, O., Sujayev, A., Turkan, F., KAYA, R., & Gülçin, İ. (2018). Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase enzymes inhibitors: The novel N,N '-bis-cyanomethylamine and alkoxymethylamine derivatives. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 32(4). https://doi.org/10.1002/jbt.22042
BibTeX
@article{taslimi2018-68084,
author = {TASLIMI, Parham and Caglayan, Cuneyt and Farzaliyev, Vagif and Nabiyev, Oruj and Sujayev, Afsun and Turkan, Fikret and KAYA, Ruya and Gülçin, İlhami},
title = {Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase enzymes inhibitors: The novel N,N '-bis-cyanomethylamine and alkoxymethylamine derivatives},
journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
year = {2018},
volume = {32},
number = {4},
issn = {1095-6670},
doi = {10.1002/jbt.22042},
url = {https://akademik.atauni.edu.tr/yayinlar/68084-synthesis-and-discovery-of-potent-carbonic-anhydrase-acetylcholinesterase}
}