Carbonic anhydrase inhibitory properties of phenolic sulfonamides derived from dopamine related compounds
Özet
The effects of some phenolic sulfonamides were determined on the cytosolic carbonic anhydrase isoenzyme I and II (hCA I and II). Both isoenzymes were purified separately from human erythrocytes, using the Sepharose-4B-L-tyrosine-sulfanilamide affinity column chromatography method. In continuation of the study, we identified the inhibitory effects of phenolic sulfonamides 1-4 on the esterase activity of hCA I, and II. The inhibitory effects of phenolic sulfonamides 1-4 were tested on human carbonic anhydrase isoenzymes hCA I, and II. Among the compounds 14, compound 1 was concluded to show the best inhibitory effects. According to our data, IC50 values of compound 1 were found as 3.55 and 2.94 mu M for hCA I, and hCA II, respectively. On the other hand, K-i values of this compound were found as 0.827 and 0.745 mu M for both isoenzymes, respectively. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.
Anahtar kelimeler
Atıf için künye
GOCER, H., AKINCIOGLU, A., Göksu, S., & Gülçin, İ. (2017). Carbonic anhydrase inhibitory properties of phenolic sulfonamides derived from dopamine related compounds. ARABIAN JOURNAL OF CHEMISTRY, 10(3), 398–402. https://doi.org/10.1016/j.arabjc.2014.08.005
BibTeX
@article{gocer2017-68057,
author = {GOCER, Hulya and AKINCIOGLU, Akin and Göksu, Süleyman and Gülçin, İlhami},
title = {Carbonic anhydrase inhibitory properties of phenolic sulfonamides derived from dopamine related compounds},
journal = {ARABIAN JOURNAL OF CHEMISTRY},
year = {2017},
volume = {10},
number = {3},
pages = {398--402},
issn = {1878-5352},
doi = {10.1016/j.arabjc.2014.08.005},
url = {https://akademik.atauni.edu.tr/yayinlar/68057-carbonic-anhydrase-inhibitory-properties-of-phenolic-sulfonamides-derived-from}
}