SYNTHESIS AND ENZYME INHIBITORY PROPERTIES OF QUINOXALINE BRIDGED BIS(IMIDAZOLIUM) SALTS
Özet
In this study, a series of new salts containing quinoxaline and imidazole moieties were synthesized in good yield by the reaction of 2,3 -bis(bromomethyl)quinoxalines and 1-alkylimidazoles in N,N-dimethylformamide. These salts were characterized by elemental analysis, IR, H-1 NMR and C-13 NMR spectroscopy, which support the proposed structures. Furthermore, the enzyme inhibition activities of these compounds were investigated. They showed highly potent inhibition effect on acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) (Ki values are in the range of 44.80 +/- 14.87 to 288.64 +/- 42.68 nM, 21.50 +/- 4.76 to 187.30 +/- 22.43 nM, and 5.81 +/- 0.71 to 164.52 +/- 26.0 nM for AChE, hCA I, and hCA II, respectively). Compound 3 showed the best inhibition effect for hCA I and compound 4 showed the best inhibition effect for hCA II and AChE.
Atıf için künye
YİĞİT, M., Demir, Y., Arinc, A., YİĞİT, B., KOCA, M., ÖZDEMİR, İ., & Gülçin, İ. (2022). SYNTHESIS AND ENZYME INHIBITORY PROPERTIES OF QUINOXALINE BRIDGED BIS(IMIDAZOLIUM) SALTS. HETEROCYCLES, 104(7), 1268–1279. https://doi.org/10.3987/com-22-14668
BibTeX
@article{yigit2022-68053,
author = {YİĞİT, MURAT and Demir, Yeliz and Arinc, Ali and YİĞİT, BEYHAN and KOCA, MURAT and ÖZDEMİR, İSMAİL and Gülçin, İlhami},
title = {SYNTHESIS AND ENZYME INHIBITORY PROPERTIES OF QUINOXALINE BRIDGED BIS(IMIDAZOLIUM) SALTS},
journal = {HETEROCYCLES},
year = {2022},
volume = {104},
number = {7},
pages = {1268--1279},
issn = {0385-5414},
doi = {10.3987/com-22-14668},
url = {https://akademik.atauni.edu.tr/yayinlar/68053-synthesis-and-enzyme-inhibitory-properties-of-quinoxaline-bridged-bisimidazolium}
}