Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives
Özet
Synthesis and carbonic anhydrase inhibitory properties of novel diarylmethylamines 22-25 and sulfonamide derivatives 26-28 were investigated. Acylation of methoxy-substituted benzenes with benzene carboxylic acids, reduction of ketones with NaBH4, conversion of alcohols to azides, Pd-C catalyzed hydrogenation of azides afforded title compounds 22-25. Compounds 22, 24 and 25 were converted to sulfonamide derivatives 26-28 with MeSO2Cl. The inhibitory effects of novel benzylamine derivatives 22-28 were tested on human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes hCA I and II. The results demonstrated that compound 28 was found to be the best inhibitor against both hCA I (K-i: 3.68 mM) and hCA II (K-i: 9.23 mM).
Anahtar kelimeler
Atıf için künye
Çetinkaya, Y., Gocer, H., Göksu, S., & Gülçin, İ. (2014). Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 29(2), 168–174. https://doi.org/10.3109/14756366.2012.763163
BibTeX
@article{cetinkaya2014-68035,
author = {Çetinkaya, Yasin and Gocer, Hulya and Göksu, Süleyman and Gülçin, İlhami},
title = {Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2014},
volume = {29},
number = {2},
pages = {168--174},
issn = {1475-6366},
doi = {10.3109/14756366.2012.763163},
url = {https://akademik.atauni.edu.tr/yayinlar/68035-synthesis-and-carbonic-anhydrase-isoenzymes-i-and-ii-inhibitory-effects-of-novel}
}