Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes

ARABACI, Betul; Gülçin, İlhami; Alwasel, Saleh

doi:10.3390/molecules190710103

Makale Tam Makale Uluslararası 2014

Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes

Betul ARABACI, İlhami Gülçin, Saleh Alwasel

MOLECULES Cilt 19 · Sayı 7 · ss. 10103–10114 · 01.07.2014

DOI ile aç

Özet

Carbonic anhydrase (CA, EC 4.2.1.1) is a zinc containing metalloenzyme that catalyzes the rapid and reversible conversion of carbon dioxide (CO2) and water (H2O) into a proton (H+) and bicarbonate (HCO3-) ion. On the other hand, capsaicin is the main component in hot chili peppers and is used extensively used in spices, food additives and drugs; it is responsible for their spicy flavor and pungent taste. There are sixteen known CA isoforms in humans. Human CA isoenzymes I, and II (hCA I and hCA II) are ubiquitous cytosolic isoforms. In this study, the inhibition properties of capsaicin against the slow cytosolic isoform hCA I, and the ubiquitous and dominant rapid cytosolic isozymes hCA II were studied. Both CA isozymes were inhibited by capsaicin in the micromolar range. This naturally bioactive compound has a Ki of 696.15 mu M against hCA I, and of 208.37 mu M against hCA II.

Anahtar kelimeler

SERIES carbonic anhydrase enzyme inhibition TROUT ONCORHYNCHUS-MYKISS ERYTHROCYTES IN-VITRO SULFONAMIDE DERIVATIVES ISOZYMES I ISOFORMS I METABOLISM Affinity chromatography enzyme purification 3 Antioxidant properties 4-DIHYDROXYPHENYL)(2 4-TRIHYDROXYPHENYL)METHANONE capsaicin RED-PEPPER

Atıf için künye

ARABACI, B., Gülçin, İ., & Alwasel, S. (2014). Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes. MOLECULES, 19(7), 10103–10114. https://doi.org/10.3390/molecules190710103

BibTeX

@article{arabaci2014-68016,
  author = {ARABACI, Betul and Gülçin, İlhami and Alwasel, Saleh},
  title = {Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes},
  journal = {MOLECULES},
  year = {2014},
  volume = {19},
  number = {7},
  pages = {10103--10114},
  issn = {1420-3049},
  doi = {10.3390/molecules190710103},
  url = {https://akademik.atauni.edu.tr/yayinlar/68016-capsaicin-a-potent-inhibitor-of-carbonic-anhydrase-isoenzymes}
}