Synthesis and biological evaluation of phloroglucinol derivatives possessing α-glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity.
Özet
A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II.
Anahtar kelimeler
Atıf için künye
Burmaoğlu, S., YILMAZ, A. B., Taslimi, P., Algul, O., Kılıç, D., & Gülçin, İ. (2018). Synthesis and biological evaluation of phloroglucinol derivatives possessing α-glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity. Archiv der Pharmazie, 351(2). https://doi.org/10.1002/ardp.201700314
BibTeX
@article{burmaoglu2018-68014,
author = {Burmaoğlu, Serdar and YILMAZ, Ahmet Berhan and Taslimi, Parham and Algul, Oztekin and Kılıç, Deryanur and Gülçin, İlhami},
title = {Synthesis and biological evaluation of phloroglucinol derivatives possessing α-glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity.},
journal = {Archiv der Pharmazie},
year = {2018},
volume = {351},
number = {2},
issn = {0365-6233},
doi = {10.1002/ardp.201700314},
url = {https://akademik.atauni.edu.tr/yayinlar/68014-synthesis-and-biological-evaluation-of-phloroglucinol-derivatives-possessing-a}
}