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Makale Tam Makale Uluslararası 2020

The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and α-Glycosidase: a Perspective for Metabolic Disorders

Yeliz Demir, Hatice Esra Duran, Lokman Durmaz, Parham Taslimi, Şükrü Beydemir, İlhami Gülçin

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY Cilt 190 · Sayı 2 · ss. 437–447 · 01.02.2020
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Özet

Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. The management of chronic pain is particularly challenging. For pain treatment, many analgesic drugs are used for their therapeutic effects. In this study, some nonsteroidal anti-inflammatory drugs including etofenamate, meloxicam, diclofenac, and tenoxicam were tested against alpha-glycosidase from Saccharomyces cerevisiae, sorbitol dehydrogenase (SDH), and aldose reductase (AR) enzymes from sheep liver. Nonsteroidal anti-inflammatory drugs demonstrated useful inhibition properties against alpha-glycosidase, AR, and SDH enzymes. K-i values were found in the range of 11.93 +/- 3.77-364.88 +/- 40.01 mu M for alpha-glycosidase, 3.36 +/- 1.08 mu M-17.68 +/- 3.39 mM for AR, and 1.68 +/- 0.02 mu M-30.98 +/- 14.31 mM for SDH. They can be selective drugs as antidiabetic agents, because of their inhibitory properties against SDH, alpha-glycosidase, and AR enzymes.

Anahtar kelimeler

enzyme inhibition BIOLOGICAL EVALUATION CRYSTAL-STRUCTURE alpha-glycosidase IN-VITRO ANTIOXIDANT aldose reductase GLUCOSIDASE INHIBITORS Nonsteroidal anti-inflammatory drugs Sorbitol dehydrogenase

Atıf için künye

Demir, Y., Duran, H. E., Durmaz, L., Taslimi, P., Beydemir, Ş., & Gülçin, İ. (2020). The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and α-Glycosidase: a Perspective for Metabolic Disorders. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 190(2), 437–447. https://doi.org/10.1007/s12010-019-03099-7

BibTeX 
@article{demir2020-68010,
  author = {Demir, Yeliz and Duran, Hatice Esra and Durmaz, Lokman and Taslimi, Parham and Beydemir, Şükrü and Gülçin, İlhami},
  title = {The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and α-Glycosidase: a Perspective for Metabolic Disorders},
  journal = {APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY},
  year = {2020},
  volume = {190},
  number = {2},
  pages = {437--447},
  issn = {0273-2289},
  doi = {10.1007/s12010-019-03099-7},
  url = {https://akademik.atauni.edu.tr/yayinlar/68010-the-influence-of-some-nonsteroidal-anti-inflammatory-drugs-on-metabolic-enzymes}
}