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Makale Tam Makale Uluslararası 2014

Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins

Yusuf AKBABA, Akin AKINCIOGLU, Hulya GOCER, Süleyman Göksu, İlhami Gülçin, Claudiu T. Supuran

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Cilt 29 · Sayı 1 · ss. 35–42 · 01.02.2014
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Özet

Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl) methane sulfonamide showed the most potent inhibitory effect against hCA I (K-i = 46 +/- 5.4 mu M, r(2) = 0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl) methanesulfonamide was found to have the best inhibitory effect against hCA II (K-i = 94 +/- 7.6 mu M, r(2) = 0.982).

Anahtar kelimeler

VIVO melatonin carbonic anhydrase phenolic compounds enzyme inhibition sulfonamide ENZYME-ACTIVITY PURIFICATION BINDING ERYTHROCYTE ISOZYMES I Acetazolamide DANTROLENE Aminoindane Aminotetralin VITRO INHIBITION

Atıf için künye

AKBABA, Y., AKINCIOGLU, A., GOCER, H., Göksu, S., Gülçin, İ., & Supuran, C. T. (2014). Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 29(1), 35–42. https://doi.org/10.3109/14756366.2012.750311

BibTeX 
@article{akbaba2014-68001,
  author = {AKBABA, Yusuf and AKINCIOGLU, Akin and GOCER, Hulya and Göksu, Süleyman and Gülçin, İlhami and Supuran, Claudiu T.},
  title = {Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins},
  journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
  year = {2014},
  volume = {29},
  number = {1},
  pages = {35--42},
  issn = {1475-6366},
  doi = {10.3109/14756366.2012.750311},
  url = {https://akademik.atauni.edu.tr/yayinlar/68001-carbonic-anhydrase-inhibitory-properties-of-novel-sulfonamide-derivatives-of}
}