Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part
Özet
An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen (F, Cl, and Br) on indeno part was described. Antioxidant and radical scavenging activities of synthesized compounds (3a-t) were determined by various in vitro assays such as 1,1-diphenyl-2-picryl-hydrazyl free radicals (DPPH center dot), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radicals (ABTS(center dot+)), N,N-dimethyl-p-phenylenediamine dihydrochloride radicals (DMPD center dot+), and superoxide anion radicals (O-2(center dot-)) scavenging, reducing ability determination by the Fe3+-Fe2+ and Cu2+-Cu+ (CUPRAC method) transformation methods, H2O2 scavenging, and ferrous ion (Fe2+) chelating activities. Moreover, these activities were compared to synthetic and standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox. The results showed that the synthesized compounds (3a-t) had effective antioxidant power. (C) 2009 Elsevier Ltd. All rights reserved.
Anahtar kelimeler
Atıf için künye
TALAZ, O., Gülçin, İ., Göksu, S., & SARAÇOĞLU, N. (2009). Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part. BIOORGANIC & MEDICINAL CHEMISTRY, 17(18), 6583–6589. https://doi.org/10.1016/j.bmc.2009.07.077
BibTeX
@article{talaz2009-67991,
author = {TALAZ, Oktay and Gülçin, İlhami and Göksu, Süleyman and SARAÇOĞLU, Nurullah},
title = {Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part},
journal = {BIOORGANIC & MEDICINAL CHEMISTRY},
year = {2009},
volume = {17},
number = {18},
pages = {6583--6589},
issn = {0968-0896},
doi = {10.1016/j.bmc.2009.07.077},
url = {https://akademik.atauni.edu.tr/yayinlar/67991-antioxidant-activity-of-510-dihydroindeno12-bindoles-containing-substituents-on}
}