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Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Hatice Kızıltaş, AHMET CEYHAN GÖREN, Zeynebe Bingol, Saleh H. Alwasel, İlhami Gülçin

RECORDS OF NATURAL PRODUCTS Cilt 15 · Sayı 6 · ss. 513–528 · 01.11.2021
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Özet

To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS(center dot+) scavenging activity, DPPH. scavenging activity, Fe(3+)reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, alpha-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 mu g/mL against acetylcholinesterase (AChE), 0.815 mu g/mL against alpha-glycosidase, and 0.675 mu g/mL against alpha-amylase.

Anahtar kelimeler

ANTIOXIDANT ACTIVITY INHIBITORS leaves alpha-amylase DERIVATIVES Acetylcholinesterase DOCKING phenolic compound alpha-glycosidase Ferula orientalis IN-VITRO ANTIOXIDANT LYOPHILIZED AQUEOUS EXTRACT MS/MS VULGARIS

Atıf için künye

Kızıltaş, H., GÖREN, A. C., Bingol, Z., Alwasel, S. H., & Gülçin, İ. (2021). Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS. RECORDS OF NATURAL PRODUCTS, 15(6), 513–528. https://doi.org/10.25135/rnp.236.21.02.1983

BibTeX 
@article{kiziltas2021-67970,
  author = {Kızıltaş, Hatice and GÖREN, AHMET CEYHAN and Bingol, Zeynebe and Alwasel, Saleh H. and Gülçin, İlhami},
  title = {Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS},
  journal = {RECORDS OF NATURAL PRODUCTS},
  year = {2021},
  volume = {15},
  number = {6},
  pages = {513--528},
  issn = {1307-6167},
  doi = {10.25135/rnp.236.21.02.1983},
  url = {https://akademik.atauni.edu.tr/yayinlar/67970-anticholinergic-antidiabetic-and-antioxidant-activities-of-ferula-orientalis-l}
}