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Makale Tam Makale Uluslararası 2018

Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes

Yakup Sari, AYDIN AKTAŞ, Parham Taslimi, YETKİN GÖK, İlhami Gülçin

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Cilt 32 · Sayı 1 · 01.01.2018
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Özet

The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted NHC precursors have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. They were tested for the inhibition of AChE and hCA enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 351.0-1269.9 nM against hCA I, 346.6-1193.1 nM against hCA II, and 19.0-76.3 nM against AChE. On the other hand, acetazolamide, a clinically used molecule, utilized as CA inhibitor, obtained a K-i value of 1246.7 nM against hCA I and 1407.6 nM against hCA II. Additionally, tacrine inhibited AChE and obtained a K-i value of 174.6 nM.

Anahtar kelimeler

ANTIOXIDANT ACTIVITY carbonic anhydrase DERIVATIVES Acetylcholinesterase Butyrylcholinesterase ERYTHROCYTES IN-VITRO ISOENZYMES I ISOZYMES I HCA I Benzimidazole BROMOPHENOLS Metal chelating HETEROCYCLIC CARBENES N-heterocyclic carbene precursors SILVER COMPLEXES SYNTHESIS

Atıf için künye

Sari, Y., AKTAŞ, A., Taslimi, P., GÖK, Y., & Gülçin, İ. (2018). Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 32(1). https://doi.org/10.1002/jbt.22009

BibTeX 
@article{sari2018-67968,
  author = {Sari, Yakup and AKTAŞ, AYDIN and Taslimi, Parham and GÖK, YETKİN and Gülçin, İlhami},
  title = {Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes},
  journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
  year = {2018},
  volume = {32},
  number = {1},
  issn = {1095-6670},
  doi = {10.1002/jbt.22009},
  url = {https://akademik.atauni.edu.tr/yayinlar/67968-novel-n-propylphthalimide-and-4-vinylbenzyl-substituted-benzimidazole-salts}
}