The effects of some bromophenols on human carbonic anhydrase isoenzymes
Özet
Carbonic anhydrases (CAs, EC 4.2.1.1), which are involved in a variety of physiological and pathological processes, are ubiquitous metalloenzymes mainly catalyzing the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and proton (H+). In this study, a dozen of bromophenol derivatives (1-12) were evaluated as metalloenzyme CA (EC 4.2.1.1) inhibitors against the human carbonic anhydrase isoenzymes I and II (hCA I and II). Cytosolic hCA I and II isoenzymes were effectively inhibited by bromophenol derivatives (1-12) with K-is in the low nanomolar range of 1.85 +/- 0.58 to 5.04 +/- 1.46 nM against hCA I and in the range of 2.01 +/- 0.52 to 2.94 +/- 1.31 nM against hCA II, respectively.
Anahtar kelimeler
Atıf için künye
TASLIMI, P., Gülçin, İ., OZTASKIN, N., Çetinkaya, Y., Göksu, S., Alwasel, S. H., & Supuran, C. T. (2016). The effects of some bromophenols on human carbonic anhydrase isoenzymes. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31(4), 603–607. https://doi.org/10.3109/14756366.2015.1054820
BibTeX
@article{taslimi2016-67967,
author = {TASLIMI, Parham and Gülçin, İlhami and OZTASKIN, Necla and Çetinkaya, Yasin and Göksu, Süleyman and Alwasel, Saleh H. and Supuran, Claudiu T.},
title = {The effects of some bromophenols on human carbonic anhydrase isoenzymes},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2016},
volume = {31},
number = {4},
pages = {603--607},
issn = {1475-6366},
doi = {10.3109/14756366.2015.1054820},
url = {https://akademik.atauni.edu.tr/yayinlar/67967-the-effects-of-some-bromophenols-on-human-carbonic-anhydrase-isoenzymes}
}