Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors
Özet
In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, -amylase, -glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Synephrine and phenylephrine had K-i values of 199.02 +/- 16.01 and 65.01 +/- 5.00M against hCA I and 336.02 +/- 74.01 and 92.04 +/- 18.03M against hCA II, respectively. On the other hand, their K-i values were found to be 169.10 +/- 80.03 and 88.03 +/- 5.01nM against AChE and 177.06 +/- 6.01 and 78.03 +/- 3.05nM against BChE, respectively. -Amylase and -glycosidase enzymes were easily inhibited by these compounds. -Glycosidase inhibitors, generally defined to as starch blockers, are anti-diabetic drugs that help to decrease post comestible blood glucose levels.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
-
SKA 3: Sağlıklı Bireyler
Atıf için künye
TASLIMI, P., Akincioglu, H., & Gülçin, İ. (2017). Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 31(11). https://doi.org/10.1002/jbt.21973
BibTeX
@article{taslimi2017-67960,
author = {TASLIMI, Parham and Akincioglu, Hulya and Gülçin, İlhami},
title = {Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors},
journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
year = {2017},
volume = {31},
number = {11},
issn = {1095-6670},
doi = {10.1002/jbt.21973},
url = {https://akademik.atauni.edu.tr/yayinlar/67960-synephrine-and-phenylephrine-act-as-amylase-glycosidase-acetylcholinesterase}
}